I have found this values works great for me:
Picture Mode Custom
Brightness at 55%
Contrast at 70%
Sharpness at 50% (at 100% oversharpened certain fonts)
Super Resolution off
Response Time Normal
Black stabilizer at 70% (I like detail in the dark scenes)
Gamma mode 4
Color Temp Custom
But Even more important for me was to switch the color control in the nvidia control panel to nvidia settings, in the default configuration I suffered from extreme black crush and it looked horrible.
Also important is to run cleartype settings to correct the halo in the fonts due to the GBR Subpixel.
After all that I am really happy with the monitor, it is miles ahead of a samsung 4k tv as a pure monitor.
Thank you for sharing. Is non-default black stabilizer advised outside of games? Also, why would you not set the response time to fast? I frankly don't understand why that's an option at all, why isn't it just locked at fast out of the factory?
Your color settings aren't calibrated for perfect accuracy, but if you like that balance, you should use what you like.
I agree that ClearType recalibration is needed, I did it a few times until I found a good balance.
Also, I found a good compromise between increasing the Windows scaling to 125% which I really did not want to do, and making text bigger. I increased global scaling in Chrome to 125%. So web pages are bigger, but otherwise everything is still scaled at 100%. Try it, it definitely makes typing and reading easier, and also subpixel rendering of larger text looks much better.